Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia.

@article{Tabakman2002NeuroprotectiveEO,
  title={Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia.},
  author={Rinat Tabakman and Philip Lazarovici and Ron Kohen},
  journal={Journal of neuroscience research},
  year={2002},
  volume={68 4},
  pages={463-9}
}
The development of neuroprotective drugs against ischemic insults is hampered by the lack of pharmacological in vitro models. We developed an ischemic model using PC12 cell cultures exposed to oxygen-glucose-deprivation (OGD) followed by reoxygenation (18 hr) under regular atmospheric oxygen level. The toxicity induced in this model, that is partially caused by generation of reactive oxygen species (ROS), was measured morphologically as well as by the release of lactate dehydrogenase (LDH) and… CONTINUE READING
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