Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage

@inproceedings{Fang2009NeuroprotectiveEO,
  title={Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage},
  author={Jiahua Fang and Xing Wang and Zhi Rong Xu and Fa Jiang},
  booktitle={BMC Neuroscience},
  year={2009}
}
Glutamate-mediated excitotoxicity, primarily through N-methyl-D-aspartate (NMDA) receptors, may be an important cause of retinal ganglion cells (RGCs) death in glaucoma and several other retinal diseases. Bis(7)-tacrine is a noncompetitive NMDA receptors antagonist that can prevent glutamate-induced hippocampal neurons damage. We tested the effects of bis(7)-tacrine against glutamate-induced rat RGCs damage in vitro and in vivo. In cultured neonatal rats RGCs, the MTT assay showed that… CONTINUE READING

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