Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease.

@article{Liang2005NeuroprotectiveEO,
  title={Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease.},
  author={Qinghua Liang and Anderson D. Smith and Stephen Pan and Vladimir A. Tyurin and Valerian E. Kagan and Teresa G Hastings and Nina Felice Schor},
  journal={Biochemical pharmacology},
  year={2005},
  volume={70 9},
  pages={
          1371-81
        }
}
TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) is a stable nitroxyl antioxidant. Previous studies have suggested that TEMPOL is protective in acute disorders thought to involve reactive oxygen species (ROS), such as ischemic stroke and cardiac reperfusion injury. Oxidized TEMPOL can be recycled to its redox-active reducing form by co-administration with polynitroxylated albumin, making it a candidate as a pharmacological "reservoir" for reducing potential of use in chronic disorders… CONTINUE READING

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Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study.

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