Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.

@article{Jin2013NeuroprotectiveEO,
  title={Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.},
  author={Jing Jin and Jennifer D Albertz and Zhihong Guo and Qi Peng and Gay L Rudow and Juan C Troncoso and Christopher A. Ross and Wenzhen Duan},
  journal={Journal of neurochemistry},
  year={2013},
  volume={125 3},
  pages={410-9}
}
Huntington's disease (HD) is a devastating genetic neurodegenerative disease caused by CAG trinucleotide expansion in the exon-1 region of the huntingtin gene. Currently, no cure is available. It is becoming increasingly apparent that mutant Huntingtin (HTT) impairs metabolic homeostasis and causes transcriptional dysregulation. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a transcriptional factor that plays a key role in regulating genes involved in energy metabolism… CONTINUE READING

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