Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1/2 MAPKs in PC12 cells.

@article{Tian2014NeuroprotectiveEO,
  title={Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1/2 MAPKs in PC12 cells.},
  author={X. Tian and Shuang Sui and J. Huang and Jun-Peng Bai and Tian-shu Ren and Qingchun Zhao},
  journal={Environmental toxicology and pharmacology},
  year={2014},
  volume={38 1},
  pages={
          189-98
        }
}
  • X. Tian, Shuang Sui, +3 authors Qingchun Zhao
  • Published 2014
  • Chemistry, Medicine
  • Environmental toxicology and pharmacology
    • Many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. In this work, protective effects of ethyl acetate extract (EAE) of Arctium lappa L. roots against glutamate-induced oxidative stress in PC12 cells were evaluated. Also, the effects of EAE on antioxidant system, mitochondrial pathway, and signal transduction pathway were explored. Pretreatment with EAE significantly increased cell viability… CONTINUE READING
    View on PubMed
    doi.org
    25 Citations
    Highly Influencial Citations
    1
    Background Citations
    10
    Methods Citations
    3
    Results Citations
    1
    25 Citations
    Citation Type

    Citation Type

    Protective Effects of Arctium lappa L. Roots Against Hydrogen Peroxide-Induced Cell Injury and Potential Mechanisms in SH-SY5Y Cells
    • 28
    Neuroprotective effects of urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells
    • 4
    • PDF
    Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells.
    • 45
    Saikosaponin-D Reduces H2O2-Induced PC12 Cell Apoptosis by Removing ROS and Blocking MAPK-Dependent Oxidative Damage
    • 22
    Neuroprotective effect of Citrus unshiu immature peel and nobiletin inhibiting hydrogen peroxide-induced oxidative stress in HT22 murine hippocampal neuronal cells
    • 17
    Lycium chinensis Mill attenuates glutamate induced oxidative toxicity in PC12 cells by increasing antioxidant defense enzymes and down regulating ROS and Ca2+ generation
    • 17
    Momordica charantia Ethanol Extract Attenuates H2O2-Induced Cell Death by Its Antioxidant and Anti-Apoptotic Properties in Human Neuroblastoma SK-N-MC Cells
    • 8
    • Highly Influenced
    • PDF
    DCMQA, a caffeoylquinic acid derivative alleviates NMDA-induced neurotoxicity via modulating GluN2A and GluN2B-containing NMDA receptors in vitro.
    • Yue Yang, H. Gao, +7 authors Qingchun Zhao
    • Chemistry, Medicine
    • Toxicology in vitro : an international journal published in association with BIBRA
    • 2020
    Caffeoylquinic Acid Derivatives Protect SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide-Induced Injury Through Modulating Oxidative Status
    • 9
    Erratum to: Caffeoylquinic Acid Derivatives Protect SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide-Induced Injury Through Modulating Oxidative Status
    • 12
    • PDF

    References

    SHOWING 1-10 OF 30 REFERENCES
    Schizandrin Protects Primary Rat Cortical Cell Cultures from Glutamate-Induced Apoptosis by Inhibiting Activation of the MAPK Family and the Mitochondria Dependent Pathway
    • 25
    • PDF
    Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca(2+) influx.
    • 70
    Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
    • Yannan Jia, Liu Ji, +5 authors Jinyong Peng
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2012
    • 40
    Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress.
    • 100
    Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis
    • 139
    • PDF
    Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells.
    • 139
    Yokukansan, a kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cells.
    • 77
    Protective effect of 3-butyl-6-bromo-1(3H)-isobenzofuranone on hydrogen peroxide-induced damage in PC12 cells
    • 21
    Reactive oxygen species mediate crosstalk between NF-κB and JNK
    • 291
    • PDF
    Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats
    • 52