Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1/2 MAPKs in PC12 cells.

@article{Tian2014NeuroprotectiveEO,
  title={Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1/2 MAPKs in PC12 cells.},
  author={X. Tian and Shuang Sui and J. Huang and Jun-Peng Bai and Tian-shu Ren and Qingchun Zhao},
  journal={Environmental toxicology and pharmacology},
  year={2014},
  volume={38 1},
  pages={
          189-98
        }
}
  • X. Tian, Shuang Sui, +3 authors Qingchun Zhao
  • Published 2014
  • Chemistry, Medicine
  • Environmental toxicology and pharmacology
  • Many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. In this work, protective effects of ethyl acetate extract (EAE) of Arctium lappa L. roots against glutamate-induced oxidative stress in PC12 cells were evaluated. Also, the effects of EAE on antioxidant system, mitochondrial pathway, and signal transduction pathway were explored. Pretreatment with EAE significantly increased cell viability… CONTINUE READING
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