Neuroprotective effect of trans-N-caffeoyltyramine from Lycium chinense against H2O2 induced cytotoxicity in PC12 cells by attenuating oxidative stress.

  title={Neuroprotective effect of trans-N-caffeoyltyramine from Lycium chinense against H2O2 induced cytotoxicity in PC12 cells by attenuating oxidative stress.},
  author={Opeyemi Joshua Olatunji and Hongxia Chen and Yifeng Zhou},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},

Figures from this paper

A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway
It is demonstrated that LyA protects against cerebral I/R injury, ameliorates oxidative damage and neuronal apoptosis, partly via activation of PKCε/Nrf2/HO-1 pathway.
Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis
The role of oxidative stress in neurodegeneration is reviewed, highlighting the potential anti-oxidation effects of natural compounds as a promising approach to develop innovative neuroprotective strategy.
Eclalbasaponin I from Aralia elata (Miq.) Seem. reduces oxidative stress-induced neural cell death by autophagy activation.
The Identification of Anthocyanins from Padus racemosa and Its Protective Effects on H2O2‐Induced INS‐1 Cells Damage and STZ‐Induced Diabetes Mice
The results suggested that APR might be a potential agent for diabetes mellitus diseases treatment and reduce the blood glucose and blood lipid in STZ‐induced diabetic mice.
Tyramine-derived hydroxycinnamic acid amides in plant foods: sources, synthesis, health effects and potential applications in food industry
The biological properties of HCAAT remain the focus in this paper, including antioxidant,Anti-inflammatory, anti-cancer, anti -diabetic, pro-melanogenesis and neuroprotective properties.
Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells
The results show that hempseed compounds can inhibit the expression of BACE 1, which is involved in the accumulation of Aβ plaques and positively affect transcription factors involved in complex and diverse biological functions.
Accelerated Solvent Extraction of Antioxidant Compounds from Gardeniae Fructus and Its Acetylcholinesterase Inhibitory and PC12 Cell Protective Activities
Gardeniae fructus is a common neuroprotective medicinal food in China, however the extraction efficiency and mixture activities are rarely mentioned. In this study, accelerated solvent extraction


Neuroprotective Effect of Baicalein on Hydrogen Peroxide-Mediated Oxidative Stress and Mitochondrial Dysfunction in PC12 Cells
Oxidative stress plays an important role in many neurodegenerative disorders. In this study, the effect of baicalein, a natural flavonoid isolated from the root of Scutellaria baicalensis G., on
Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models.
Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus
Herbal formulation SR10, comprising Radix Astragali, Radix Codonopsis and Cortex Lycii, was examined for its antidiabetic and antioxidative effects using the diabetic +db/+db mouse model and showed that SR10 was effective in decreasing the blood glucose level in chronic treatment by improving β‐cell function.
Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice
Oral administration of ELC before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase, suggesting gastroprotective properties of L. chinense.
Changes in mitochondrial membrane potential during oxidative stress‐induced apoptosis in PC12 cells
Observations suggest that the oxidative stress triggers apoptosis associated with both increased generation of ROS and decreases in level of ΔΨm and that BCL‐2 prevents cell death as well as Δ Ψm but not ROS production.
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Recognition of upstream and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal damage as well as free radical scavenging.
Hypoglycemic effects and mechanisms of action of Cortex Lycii Radicis on alloxan-induced diabetic mice.
The results indicate that CLR alleviates the blood glucose and lipid increases associated with diabetes and improves the abnormal glucose metabolism and increases insulin secretion by restoring impaired pancrease beta-cells in alloxan-induced diabetic mice and suggest that CLR has hypoglycemic potential and could be useful in diabetes therapy.
Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
It is shown that not all autophagy inducers significantly increase ROS, and that the potential benefits in neurodegenerative diseases of some classes of antioxidants may be compromised by their autophagic-blocking properties.