Neuroprotective effect of sulfhydryl reduction in a rat optic nerve crush model.

@article{Swanson2005NeuroprotectiveEO,
  title={Neuroprotective effect of sulfhydryl reduction in a rat optic nerve crush model.},
  author={Kyle I. Swanson and Christopher R. Schlieve and Christopher J. Lieven and Leonard A Levin},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 10},
  pages={3737-41}
}
PURPOSE The signaling of retinal ganglion cell (RGC) death after axotomy is partly dependent on the generation of reactive oxygen species. Shifting the RGC redox state toward reduction is protective in a dissociated mixed retinal culture model of axotomy. The hypothesis for the current study was that tris(2-carboxyethyl)phosphine (TCEP), a sulfhydryl reductant, would protect RGCs in a rat optic nerve crush model of axotomy. METHODS RGCs of postnatal day 4 to 5 Long-Evans rats were… CONTINUE READING

2 Figures & Tables

Connections & Topics

Mentioned Connections BETA
The hypothesis for the current study was that tris(2-carboxyethyl)phosphine ( TCEP ) , a sulfhydryl reductant , would protect RGCs in a rat optic nerve crush model of axotomy .
The hypothesis for the current study was that tris(2-carboxyethyl)phosphine ( TCEP ) , a sulfhydryl reductant , would protect RGCs in a rat optic nerve crush model of axotomy .
All Topics