Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway.

Abstract

In the current study, we aimed to investigate the mechanistic role of DJ-1/PI3K/Akt survival pathway in ischemia/reperfusion (I/R) induced cerebral damage and to investigate if the resveratrol (RES) mediates its ischemic neuroptotection through this pathway. RES administration to Sham rats boosted glutathione level and superoxide dismutase activity and… (More)

Topics

9 Figures and Tables

Statistics

02040608020162017
Citations per Year

Citation Velocity: 20

Averaging 20 citations per year over the last 2 years.

Learn more about how we calculate this metric in our FAQ.