Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice.

@article{Aggarwal2008NeuroprotectiveEO,
  title={Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice.},
  author={Raman Aggarwal and Bikash Medhi and Ashis Pathak and Veena Dhawan and Amitava Chakrabarti},
  journal={The Journal of pharmacy and pharmacology},
  year={2008},
  volume={60 6},
  pages={731-7}
}
The possible neuroprotective effect of progesterone, a steroid hormone, on acute phase changes in a mouse model of cerebral ischaemia induced by bilateral common carotid artery occlusion (BCAO) was studied. A total of 72 male mice were included in the study. The BCAO model was used to induce partial global cerebral ischaemia. Morphological assessment included measurement of infarct size and brain oedema. Post-ischaemic seizure susceptibility was assessed using a subconvulsive dose of… CONTINUE READING

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