Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.

@article{Kumon2000NeuroprotectiveEO,
  title={Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.},
  author={Yoshiko Kumon and Soon Chul Kim and Paul Tompkins and Andrew Stevens and Saburo Sakaki and Christopher Miranda Loftus},
  journal={Journal of neurosurgery},
  year={2000},
  volume={92 5},
  pages={848-52}
}
OBJECT Exogenous progesterone has been shown to reduce brain edema and ischemia-induced cell damage and to improve physiological and neurological function during the early stage of focal cerebral ischemia. In the present study, the authors assessed the neuroprotective potential of progesterone during the late stage of ischemia in a transient middle cerebral artery (MCA) occlusion model in the rat. METHODS Forty-eight male spontaneously hypertensive rats were randomly assigned to six groups… CONTINUE READING

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