Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis.

@article{ChangHong2005NeuroprotectiveEO,
  title={Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis.},
  author={Ren Chang-Hong and Manabu Wada and Shingo Koyama and Hideki Kimura and Shigeki Arawaka and Toru Kawanami and Keiji Kurita and Toshihiko Kadoya and Masashi Aoki and Y. Itoyama and Takeo Kato},
  journal={Experimental neurology},
  year={2005},
  volume={194 1},
  pages={203-11}
}
Abnormal accumulation of neurofilaments in motor neurons is a characteristic pathological finding in amyotrophic lateral sclerosis (ALS). Recently, we revealed that galectin-1, whose oxidized form has axonal regeneration-enhancing activity, accumulates in the neurofilamentous lesions in ALS. To investigate whether oxidized galectin-1 has a beneficial effect… CONTINUE READING