Neuroprotective effect of gamma-hydroxybutyrate in transient global cerebral ischemia in the rat.

@article{Vergoni2000NeuroprotectiveEO,
  title={Neuroprotective effect of gamma-hydroxybutyrate in transient global cerebral ischemia in the rat.},
  author={Anna Valeria Vergoni and Alessandra Ottani and Annibale R. Botticelli and Davide Zaffe and L Guano and Antonella Loche and Susanna Genedani and Gian Luigi Gessa and Alfio Bertolini},
  journal={European journal of pharmacology},
  year={2000},
  volume={397 1},
  pages={75-84}
}
The effect of gamma-hydroxybutyrate on the histological and behavioral consequences of transient brain ischemia was studied in the four vessel occlusion rat model. In saline-treated animals, 30 min ischemia caused a massive loss of neurons in the hippocampal CA1 subfield (normal neurons: 14%, 5%, 23% and 30% on the 3rd, 10th, 15th and 65th day after ischemia, respectively). gamma-Hydroxybutyrate - 300 mg/kg intraperitoneally (i.p.) 30 min before or 10 min after arteries occlusion, followed by… CONTINUE READING
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