Neuroprotective effect of flupirtine in prion disease.

  title={Neuroprotective effect of flupirtine in prion disease.},
  author={Heinz C. Schr{\"o}der and Werner E. G. M{\"u}ller},
  journal={Drugs of today},
  volume={38 1},
Apoptotic neuronal cell death is a hallmark of prion diseases. The apoptotic process in neuronal cells is thought to be caused by the scrapie prion protein, PrPSc, and can be experimentally induced by its peptide fragment, PrP106-126. This process is a target for potential drugs to combat prion disease or to ameliorate its symptoms. Flupirtine (Katadolon), a pyridine derivative that is in clinical use as a nonopioid analgesic, has a potent cytoprotective effect, at concentrations above 1 microg… CONTINUE READING
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