Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation.

@article{Lonergan2002NeuroprotectiveEO,
  title={Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation.},
  author={Peter E Lonergan and Darren S D Martin and David F. Horrobin and Marina A. Lynch},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 23},
  pages={20804-11}
}
Exposure to irradiation leads to detrimental changes in several cell types. In this study we assessed the changes induced in hippocampus by exposure of rats to whole body irradiation; the findings reveal that irradiation leads to apoptotic cell death in hippocampus, and as a consequence, long term potentiation in perforant path-granule cell synapses is markedly impaired. The evidence is consistent with the view that irradiation induced an increase in reactive oxygen species and that this leads… CONTINUE READING