Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of astrocytic protein in the hippocampus.

@article{Mani2017NeuroprotectiveEO,
  title={Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of astrocytic protein in the hippocampus.},
  author={Renuka Mani and Vijayakumar Natesan and Ramakrishnan Arumugam},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={88},
  pages={
          762-769
        }
}
Neuroinflammation is an innate immune response in the central nervous system (CNS) against metabolic and pathogenic toxic wastes. The main hypothesis implies that a state of hyperammonemia which is accountable for both direct and indirect modification in ammonia metabolism with an elevated production of inflammatory cytokines. This study was constructed to explore the modulating effect of chrysin on rudimentary pathophysiologic mechanisms of ammonium chloride (NH4Cl) mediated neuroinflammation… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Resveratrol Prevents Ammonia Toxicity in Astroglial Cells
  • 53
  • PDF
Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: A dose dependent study.
  • 18
Direct Evidence for Central Proinflammatory Mechanisms in Rats with Experimental Acute Liver Failure: Protective Effect of Hypothermia
  • W. Jiang, P. Desjardins, R. Butterworth
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
  • 102
Neurobiology of ammonia
  • 542
Oxidative and nitrosative stress in ammonia neurotoxicity
  • 23
Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity
  • 100
...
1
2
3
4
5
...