Neuroprotective effect of carnosine on necrotic cell death in PC12 cells

@article{Shen2007NeuroprotectiveEO,
  title={Neuroprotective effect of carnosine on necrotic cell death in PC12 cells},
  author={Yao Shen and Yanying Fan and Haibin Dai and Qiuli Fu and Zhong Chen},
  journal={Neuroscience Letters},
  year={2007},
  volume={414},
  pages={145-149}
}
  • Yao Shen, Yanying Fan, +2 authors Zhong Chen
  • Published 2007
  • Medicine, Biology
  • Neuroscience Letters
  • The nervous tissue of many vertebrates, including humans, can synthesize beta-alanyl-L-histidine (carnosine). The biological functions of carnosine are still open to question, although several theories supported by strong experimental data have been proposed. The objective of this study was to examine the effects of carnosine on neurotoxicity in differentiated rat pheochromocytoma (PC12) cells. Neurotoxicity was induced by N-methyl-D-aspartate (NMDA), which caused time- and concentration… CONTINUE READING

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