Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.

@article{Saito1998NeuroprotectiveEO,
  title={Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.},
  author={Ikuo Saito and Takao Asano and Keiji Sano and Kintomo Takakura and Hiroshi Abe and Takashi Yoshimoto and H. Ishikura K. Kikuchi and Takashi Ohta and Saiko Ishibashi},
  journal={Neurosurgery},
  year={1998},
  volume={42 2},
  pages={269-77; discussion 277-8}
}
OBJECTIVE The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was evaluated in a multicenter placebo-controlled double-blind clinical trial. METHODS Patients who suffered aneurysmal subarachnoid hemorrhages of Hunt and Kosnik Grades II through IV at admission and were able to start drug treatment within 96 hours of the ictus were enrolled. Early surgery was performed whenever… CONTINUE READING