Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain.

@article{Cash2001NeuroprotectiveEO,
  title={Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain.},
  author={Diana Cash and J. S. Beech and Richard C Rayne and Philip M Bath and Brian S. Meldrum and S. C. Williams},
  journal={Brain research},
  year={2001},
  volume={905 1-2},
  pages={91-103}
}
Using serial magnetic resonance imaging we have evaluated the effectiveness of aminoguanidine (AG) as a neuroprotective agent in a rat model of transient middle cerebral artery occlusion (MCAO). Because aminoguanidine's neuroprotective properties have primarily been ascribed to its action as iNOS inhibitor, we also performed a biochemical analysis of nitric oxide metabolites and NOS isoforms in our model of ischaemia. Daily injections of AG (100 mg/kg) or saline, were started at 6 h after the… CONTINUE READING
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