Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.

@article{Neymotin2011NeuroprotectiveEO,
  title={Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.},
  author={Arie Neymotin and Noel Ylagan Calingasan and Elizabeth J. Wille and Nima Naseri and Susanne Petri and Maria Damiano and Karen T. Liby and Renee Risingsong and Michael B. Sporn and Myron Flint Beal and Mahmoud Kiaei},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 1},
  pages={88-96}
}
Oxidative damage, neuroinflammation, and mitochondrial dysfunction contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), and these pathologic processes are tightly regulated by the Nrf2/ARE (NF-E2-related factor 2/antioxidant response element) signaling program. Therefore, modulation of the Nrf2/ARE pathway is an attractive therapeutic target for neurodegenerative diseases such as ALS. We examined two triterpenoids, CDDO (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid… CONTINUE READING