Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity.

  title={Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity.},
  author={Bruno Ara{\'u}jo Rego Santos Silva and Alberto C. P. Dias and Federico Ferreres and Jo{\~a}o Oliveira Malva and Catarina Resende de Oliveira},
  journal={Neurotoxicity research},
  volume={6 2},
In the present study we assessed the neuroprotective role of a Hypericum perforatum ethanolic extract and obtained fractions in amyloid-beta peptide (Abeta)((25-35))-induced cell death in rat cultured hippocampal neurons. Lipid peroxidation was used as a marker of oxidative stress by following the formation of TBARS in rat cortical synaptosomes, after incubation with ascorbate/Fe2+, alone or in the presence of EC97 effective concentrations of H. perforatum fractions. Induced lipid peroxidation… CONTINUE READING
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