Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil.

@article{Tokime1996NeuroprotectiveEO,
  title={Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil.},
  author={T Tokime and Kazuhiko Nozaki and Hirotoshi Kikuchi},
  journal={Neuroscience letters},
  year={1996},
  volume={206 2-3},
  pages={81-4}
}
Delayed neuronal death (DND) in CA1 region after transient global ischemia is a well-known phenomenon, but its mechanism has not been clarified. In order to examine the involvement of nitric oxide (NO) in DND, 7-nitro indazole (7NI), a selective neuronal NO synthase (nNOS) inhibitor, and FK506, an immunosuppressant which also inhibits nNOS, were administered intraperitoneally during and after transient global ischemia in gerbil. FK506 moderately ameliorated DND in a dose-dependent manner… CONTINUE READING