• Corpus ID: 27161343

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.

@article{Prez2000NeuroprotectiveAO,
  title={Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.},
  author={Virgili P{\'e}rez and J A Mor{\'o}n and M Past{\'o} and Mercedes Unzeta},
  journal={Neurobiology},
  year={2000},
  volume={8 3-4},
  pages={
          231-6
        }
}
PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this… 

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