• Corpus ID: 27161343

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.

  title={Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.},
  author={Virgili P{\'e}rez and J A Mor{\'o}n and M Past{\'o} and Mercedes Unzeta},
  volume={8 3-4},
PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this… 

Protective effect of N‐(2‐propynyl)‐2‐(5‐benzyloxy‐indolyl) methylamine (PF 9601N), a novel MAO‐B inhibitor, on dopamine‐lesioned PC12 cultured cells

The results indicated that, besides the intracellular toxicity effect of dopamine, another non‐specific extracellular mechanism could be involved in the pathogenesis of Parkinson's disease.

The central histamine level in rat model of vascular dementia.

The rat vascular dementia model supports deficiency in histaminergic system in VD because of drastically increased latency and run time following permanent bilateral occlusion of the common carotid arteries leading to chronic cerebral hypoperfusion.

Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia.

Evaluated in vivo the novel compounds - ASS188 and ASS234 - which combine the benzylpiperidine moiety of the acetylcholinesteras (AChE) inhibitor donepezil and the indolyl propargylamino moieties of the monoaminooxidase (MAO) inhibitor, with respect to their influence on cerebral amine neurotransmitters systems and neuroprotective activity are evaluated.