Neuroprotective and neurorestorative strategies for neuronal injury

  title={Neuroprotective and neurorestorative strategies for neuronal injury},
  author={Myron Flint Beal and Tom{\'a}s Palomo and Richard M. Kostrzewa and Trevor Archer},
  journal={Neurotoxicity Research},
Mechanisms of neuronal cell death in apoptosis and necrosis are examined. Neurotoxic processes underlying cellular destruction may involve N-methyl-D-aspartate (NMDA) receptor activation and/or activation of neuronal nitric oxide synthase but the depletion of energy and generation of free radicals appears to be critical. In Alzheimer’s disease the damaging effects of peroxynitrite and exposure to β-amyloid peptide is evident. Mitochondrial dysfunction is involved in several neurodegenerative… CONTINUE READING
6 Citations
96 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 96 references

Cardioprotective effect of alphatocopherol , ascorbate , deferoxamine , and deferiprone : mitochondrial junction in cultured , ironloaded heart cells

  • G. Link, A. M. Konijn, C. Hersko
  • Science
  • 1999
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…