Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.

@article{Arce2009NeuroprotectiveAC,
  title={Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.},
  author={Mariana P Arce and Mar{\'i}a Isabel Rodr{\'i}guez-Franco and Gema C Gonz{\'a}lez-Mu{\~n}oz and Concepcion Perez and Beatriz L{\'o}pez and M{\'e}rcedes Villarroya and Manuela G L{\'o}pez and Antonio G Garc{\'i}a and Santiago Conde},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 22},
  pages={
          7249-57
        }
}
Novel multifunctional compounds have been designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease (AD). With an L-glutamic moiety as a suitable biocompatible linker, three pharmacophoric groups were joined: (1) an N-benzylpiperidine fragment selected to inhibit acetylcholinesterase by interacting with the catalytic active site (CAS), (2) an N-protecting group of the amino acid, capable of interacting with the acetylcholinesterase (AChE)-peripheral… CONTINUE READING

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