Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid.

  title={Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid.},
  author={Savita Khanna and Han-A Park and Chandan K. Sen and Trimurtulu Golakoti and Krishanu Sengupta and Somepalli Venkateswarlu and Sashwati Roy},
  journal={Antioxidants & redox signaling},
  volume={11 3},
A demethylated derivative of curcumin (DC; 67.8% bisdemethylcurcumin, 20.7% demethylmonodemethoxycurcumin, 5.86% bisdemethoxycurcumin, 2.58% demethylcurcumin) was prepared by using a 95% extract of curcumin (C(95); 72.2% curcumin, 18.8% monodemethoxycurcumin, 4.5% bisdemethoxycurcumin). DC increased glutathione and reduced reactive oxygen species (ROS) in HT4 neuronal cells. In a model of glutamate-induced death of HT4, DC was more effective than C(95) in neuroprotection. The protective effects… CONTINUE READING


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