Neuroprotective and Anti-inflammatory Effects of a Dodecamer Peptide Harboring Ninjurin 1 Cell Adhesion Motif in the Postischemic Brain

@article{Lee2017NeuroprotectiveAA,
  title={Neuroprotective and Anti-inflammatory Effects of a Dodecamer Peptide Harboring Ninjurin 1 Cell Adhesion Motif in the Postischemic Brain},
  author={Hye-Kyung Lee and Il-Doo Kim and Hahnbie Lee and Lidan Luo and Seung-Woo Kim and Ja-Kyeong Lee},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={6094-6111}
}
It has been reported that the innate immune response plays important roles in brain ischemia and that the infiltration of blood-derived immune cells is a key initiator of this response. Nerve injury-induced protein 1 (Ninjurin 1, Ninj1) is a cell adhesion molecule responsible for cell-to-cell interactions between immune cells and endothelial cells. In the present study, we investigated the proinflammatory and neuroprotective effects of Ninj1 and a dodecamer peptide harboring Ninj1 N-terminal… CONTINUE READING
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