Neuroprotective and Abstinence-Promoting Effects of Acamprosate

@article{Witte2005NeuroprotectiveAA,
  title={Neuroprotective and Abstinence-Promoting Effects of Acamprosate},
  author={Philippe de Witte and John M. Littleton and Philippe Parot and George K. Koob},
  journal={CNS Drugs},
  year={2005},
  volume={19},
  pages={517-537}
}
Acamprosate is an abstinence-promoting drug widely used in the treatment of alcohol dependence but which has a mechanism of action that has remained obscure for many years. Recently, evidence has emerged that this drug may interact with excitatory glutamatergic neurotransmission in general and as an antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5) in particular. These findings provide, for the first time, a satisfactory, unifying hypothesis that can bring together and… Expand
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