• DOI:10.1016/S0028-3908(01)00175-7
Corpus ID: 24194421

Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

@article{He2002NeuroprotectiveAR,
  title={Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function},
  author={Y. He and A. Benz and T. Fu and M. Wang and S. Mennerick},
  journal={Neuropharmacology},
  year={2002},
  volume={42},
  pages={199-209}
}

Y. He, A. Benz, +2 authors S. Mennerick

Published 2002

Chemistry, Medicine

Neuropharmacology

The antiepileptic drug riluzole is a use-dependent blocker of voltage-gated Na(+) channels and selectively depresses action potential-driven glutamate over gamma-aminobutyric acid (GABA) release. Here we report that in addition to its presynaptic effect, riluzole at higher concentrations also strongly potentiates postsynaptic GABA(A) responses both in cultured hippocampal neurons and in Xenopus oocytes expressing recombinant receptors. Although peak inhibitory postsynaptic currents (IPSCs) of… CONTINUE READING

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