Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

@article{He2002NeuroprotectiveAR,
  title={Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function},
  author={Y. He and Ann M. Benz and Tao Fu and M. Wang and Douglas F Covey and Charles F. Zorumski and Steven J. Mennerick},
  journal={Neuropharmacology},
  year={2002},
  volume={42},
  pages={199-209}
}
Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABAA-receptors
TLDR
Three different molecular mechanisms of interaction of the neuroprotective compound riluzole were observed at two different subtypes of GABAA receptor channels, pointing to the impact of the inhibitory as well as the excitatory synaptic activity as a pharmacological target to counteract chronic excitotoxicity.
Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole
TLDR
An interaction of riluzole with glutamatergic neurotransmission in spinal cord motor neurons is revealed and can contribute to explain its beneficial effect in the ALS treatment.
Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn
Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro
TLDR
Controlling NMDA receptor function and, thus, excitatory transmitter release via modulation of PKC suggests a novel potential target to contrast glutamate excitotoxicity in this motor nucleus.
The Interaction of the Neuroprotective Compounds Riluzole and Phenobarbital with AMPA-Type Glutamate Receptors: A Patch-Clamp Study
TLDR
Riluzole and phenobarbital modulate AMPA-type receptor channels separately, which could be both characterized as a combination of open-channel block and competitive-block mechanism.
Interaction of Riluzole with the Closed Inactivated State of Kv4.3 Channels
TLDR
The results suggest that riluzole inhibits Kv4.3 by binding to the closed inactivated state of the channels and that the unbinding of rILuzole occurs from the closed state during depolarization.
Riluzole, neuroprotection and amyotrophic lateral sclerosis.
TLDR
The present review summarises the known chemical and pharmacological properties of riluzole, and the hypothesis that Na+ conductances may be involved in the processes of neuronal and axonal degeneration in ALS will be explored.
Riluzole in the Treatment of Mood and Anxiety Disorders
TLDR
Riluzole may hold promise for the treatment of several psychiatric conditions, possibly through its ability to modulate pathologically dysregulated glutamate levels, and merits further investigation.
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