Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function

@article{He2002NeuroprotectiveAR,
  title={Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function},
  author={Y. He and A. Benz and T. Fu and M. Wang and S. Mennerick},
  journal={Neuropharmacology},
  year={2002},
  volume={42},
  pages={199-209}
}
  • Y. He, A. Benz, +2 authors S. Mennerick
  • Published 2002
  • Chemistry, Medicine
  • Neuropharmacology
  • The antiepileptic drug riluzole is a use-dependent blocker of voltage-gated Na(+) channels and selectively depresses action potential-driven glutamate over gamma-aminobutyric acid (GABA) release. Here we report that in addition to its presynaptic effect, riluzole at higher concentrations also strongly potentiates postsynaptic GABA(A) responses both in cultured hippocampal neurons and in Xenopus oocytes expressing recombinant receptors. Although peak inhibitory postsynaptic currents (IPSCs) of… CONTINUE READING
    58 Citations
    Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABAA-receptors
    • 24
    • Highly Influenced
    Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole
    • 60
    Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury
    • 57
    Interaction of Riluzole with the Closed Inactivated State of Kv4.3 Channels
    • 21
    • PDF
    Riluzole, neuroprotection and amyotrophic lateral sclerosis.
    • 204
    Glutamate modulators as novel interventions for mood disorders.
    • 47
    • PDF

    References

    SHOWING 1-10 OF 29 REFERENCES
    Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes.
    • 58
    GABAA receptor channels.
    • 1,922