Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells.

@article{Chen2013NeuroprotectiveAO,
  title={Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells.},
  author={Wenna Chen and Ximing Li and Lian-qun Jia and Jun Wang and Lin Zhang and Diandong Hou and Junyan Wang and Lu Ren},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 5},
  pages={1140-52}
}
BACKGROUND AND PURPOSE Neurodegenerative diseases present progressive neurological disorder induced by cell death or apoptosis. Catalpol, an iridoid glucoside isolated from the root of Rehmannia glutinosa Libosch, is present in a wide range of plant families. Although catalpol is an effective anti-apoptotic agent in LPS-induced neurodegeneration, the underlying mechanism has not been established. Here we have identified some of the mechanisms involved the prevention by catalpol of apoptosis… CONTINUE READING

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