Neuroprotective actions of pyridoxine.

  title={Neuroprotective actions of pyridoxine.},
  author={Krishnamurti Dakshinamurti and Sushil Kumar Sharma and Jonathan Geiger},
  journal={Biochimica et biophysica acta},
  volume={1647 1-2},
Electroencephalographic recordings in cerebral cortex of mice given a single sub-convulsive dose of domoic acid exhibited typical spike and wave discharges. Administration of the anti-epileptic drugs sodium valproate, nimodipine, or 5 alpha-pregnan 3 alpha-ol-20-one as well as pyridoxine simultaneously with or after domoic acid treatment resulted in significantly less spike and wave activity. Administration of these same drugs 45 min prior to the administration of domoic acid also significantly… CONTINUE READING


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