Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy.

@article{Iwasaki2002NeuroprotectiveAO,
  title={Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy.},
  author={Yasuo Iwasaki and Yasumitsu Ichikawa and Osamu Igarashi and Kounosuke Iwamoto and Masao Kinoshitata and Ken Ikeda},
  journal={Neurological research},
  year={2002},
  volume={24 6},
  pages={573-6}
}
We show that nonimmunosuppressive analogues of the immunosuppressive drugs FK506 and cyclosporin A (CsA) rescue axotomized neonatal motor neuron death. Unilateral sciatic nerve was transected in neonatal rats. Animals were then treated daily with different doses of FK506 and CsA for 14 days with intraperitoneal injection. Control rats received phosphate buffer saline (PBS) in the same fashion. After treatment, the number of spinal motor neurons was determined at L4 level. In comparison with… CONTINUE READING