Neuroprotective action of lithium in disorders of the central nervous system.

  title={Neuroprotective action of lithium in disorders of the central nervous system.},
  author={Chi-Tso Chiu and D. M. Chuang},
  journal={Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences},
  volume={36 6},
Substantial in vitro and in vivo evidence of neurotrophic and neuroprotective effects of lithium suggests that it may also have considerable potential for the treatment of neurodegenerative conditions. Lithium's main mechanisms of action appear to stem from its ability to inhibit glycogen synthase kinase-3 activity and also to induce signaling mediated by brain-derived neurotrophic factor. This in turn alters a wide variety of downstream effectors, with the ultimate effect of enhancing pathways… CONTINUE READING
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