Neuroprotective Efficacy and Therapeutic Window of the High-Affinity N-Methyl-D-aspartate Antagonist Conantokin-G : In Vitro ( Primary Cerebellar Neurons ) and In Vivo ( Rat Model of Transient Focal Brain Ischemia ) Studies 1

@inproceedings{Williams2000NeuroprotectiveEA,
  title={Neuroprotective Efficacy and Therapeutic Window of the High-Affinity N-Methyl-D-aspartate Antagonist Conantokin-G : In Vitro ( Primary Cerebellar Neurons ) and In Vivo ( Rat Model of Transient Focal Brain Ischemia ) Studies 1},
  author={Antony J. Williams and Jitendra R. Dave and James B Phillips and Yu Kun Lin and R. Tyler McCabe and Frank C. Tortella},
  year={2000}
}
Conantokin-G (Con-G), a 17-amino-acid peptide derived from marine snails and a potent N-methyl-D-aspartate (NMDA) antagonist, was evaluated for its neuroprotective properties in vitro and in vivo. In primary cerebellar neurons, Con-G was shown to decrease excitotoxic calcium responses to NMDA and to exhibit differential neuroprotection potencies against… CONTINUE READING