Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis‐apovincaminic Acid on NMDA‐Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model

@article{Nyakas2009NeuroprotectiveEO,
  title={Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis‐apovincaminic Acid on NMDA‐Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model},
  author={C. Nyakas and K. Felszeghy and R. Szab{\'o} and J. Keijser and P. Luiten and Z. Szombathelyi and K. Tihanyi},
  journal={CNS Neuroscience \& Therapeutics},
  year={2009},
  volume={15}
}
Vinpocetine (ethyl‐apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and treatment of cerebrovascular diseases predisposing to development of dementia. Both vinpocetine and its main metabolite cis‐apovincaminic acid (cAVA) exert a neuroprotective type of action. Bilateral N‐methyl‐D‐aspartate (NMDA)‐induced neurodegeneration in the entorhinal cortex of rat was used as a dementia model to confirm the… Expand
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