Neuroprotective Effects of Kinetin Against Glutamate-Induced Oxidative Cytotoxicity in HT22 Cells: Involvement of Nrf2 and Heme Oxygenase-1

@article{Wei2017NeuroprotectiveEO,
  title={Neuroprotective Effects of Kinetin Against Glutamate-Induced Oxidative Cytotoxicity in HT22 Cells: Involvement of Nrf2 and Heme Oxygenase-1},
  author={Yunpeng Wei and D. -H. Liu and Yin Zheng and Chaoshuang Hao and Honglian Li and Wuqing Ouyang},
  journal={Neurotoxicity Research},
  year={2017},
  volume={33},
  pages={725-737}
}
Oxidative stress is considered as one of key factors related to Alzheimer’s disease (AD), while kinetin (KT) has been reported to exert anti-oxidative activities as well as neuroprotective effects both in vivo and in vitro. Thus, in this study, the neuroprotective effects of KT against glutamate-induced oxidative toxicity in HT22 cells were investigated. To evaluate the anti-oxidative capabilities of KT itself, several anti-oxidative assays in vitro were conducted. To evaluate the… CONTINUE READING
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