Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice.

@article{Chen2016NeuroprotectiveEO,
  title={Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice.},
  author={Yi-jing Chen and Hai-Yang Zheng and Xiu-Xian Huang and Shuang-Xue Han and Dongsheng Zhang and Jia-Zuan Ni and Xiao-Yang He},
  journal={CNS neuroscience & therapeutics},
  year={2016},
  volume={22 1},
  pages={63-73}
}
AIMS This study investigated the neuroprotective properties of icariin (an effective component of traditional Chinese herbal medicine Epimedium) on neuronal function and brain energy metabolism maintenance in a triple-transgenic mouse model of Alzheimer's disease (3 × Tg-AD). METHODS 3 × Tg-AD mice as well as primary neurons were subjected to icariin treatment. Morris water maze assay, magnetic resonance spectroscopy (MRS), Western blotting, ELISA, and immunohistochemistry analysis were used… CONTINUE READING
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