Neuroprotective Effect of PACAP on Translational Control Alteration and Cognitive Decline in MPTP Parkinsonian Mice

@article{Deguil2009NeuroprotectiveEO,
  title={Neuroprotective Effect of PACAP on Translational Control Alteration and Cognitive Decline in MPTP Parkinsonian Mice},
  author={Julie Deguil and François Chavant and Claire Lafay-Chebassier and Marie-Christine P{\'e}rault-Pochat and Bernard Fauconneau and St{\'e}phanie Pain},
  journal={Neurotoxicity Research},
  year={2009},
  volume={17},
  pages={142-155}
}
Parkinson’s disease (PD) is characterized by a triade of motor symptoms due to the degeneration of nigrostriatal pathway. In addition to these motor impairments, cognitive disturbances have been reported to occur in PD patients in the early stage of the disease. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin widely used to produce experimental models of PD. In a previous work, we showed that MPTP altered the expression of proteins involved in mTOR antiapoptotic and PKR… CONTINUE READING

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