Neuroprotective Effect of GK-2, a Dipeptide Mimetic of Nerve Growth Factor, during Experimental Focal Ischemia in Middle Cerebral Artery Basin

@article{Seredenin2011NeuroprotectiveEO,
  title={Neuroprotective Effect of GK-2, a Dipeptide Mimetic of Nerve Growth Factor, during Experimental Focal Ischemia in Middle Cerebral Artery Basin},
  author={Sergey B. Seredenin and Denis N. Silachev and Tatyana A. Gudasheva and Yuri A. Pirogov and Nickolay K. Isaev},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2011},
  volume={151},
  pages={584-587}
}
Magnetic resonance tomography, staining with triphenyltetrazolium chloride, and tests for evaluation of functional disturbances “cylinder” and “limb stimulation” showed that daily intraperitoneal injection of dipeptide mimetic of nerve growth factor GK-2 (1 mg/kg) for 6 days to rats with experimental focal ischemia provoked by unilateral intravascular occlusion of a branch of the middle cerebral artery significantly improved neurological defi cit and decreased the infarction area. 
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