Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway

@article{Gao2011NeuroprotectiveEO,
  title={Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway},
  author={Yonglin Gao and Chaohua Dong and Jungang Yin and Jingyu Shen and J. Tian and Chunmei Li},
  journal={Cellular and Molecular Neurobiology},
  year={2011},
  volume={32},
  pages={523-529}
}
One of the plausible ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of endogenous antioxidant defense capacity. In this study, we investigated the neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 cells and the possible signaling pathways involved. The results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in H2O2-induced PC12… Expand
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