Neuroprotective Effect of DAHK Peptide in an Occlusive Model of Permanent Focal Ischemia in Rats

@article{DazRuz2009NeuroprotectiveEO,
  title={Neuroprotective Effect of DAHK Peptide in an Occlusive Model of Permanent Focal Ischemia in Rats},
  author={Araceli D{\'i}az-Ru{\'i}z and Camilo R{\'i}os and Joselyn Carvajal-Sotelo and Alma Ort{\'i}z-Plata and Gerardo Pavel Espino-Sol{\'i}s and Marisela M{\'e}ndez-Armenta and Sergio Montes and Antonio Monroy-Noyola},
  journal={Neurochemical Research},
  year={2009},
  volume={35},
  pages={343-347}
}
This study examined the neuroprotective ability of tetrapeptide l-Asp-Ala-His-Lys (DAHK) in permanent middle cerebral artery occlusion in rats. One DAHK dose (16 mg/kg) or saline solution were i.v. administered 30 min after occlusion and neurological deficit was evaluated at 2, 24, 48, 72 and 96 h using Longa scoring scale. The striatum infarction area was evaluated until 96 h after occlusion in both groups after staining with hematoxylin–eosin. DAHK-treated group showed a significant (P < 0.05… CONTINUE READING