Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways

  title={Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways},
  author={Katsutoshi Furukawa and Steven Estus and Weiming Fu and Robert J. Mark and Mark P. Mattson},
  journal={The Journal of Cell Biology},
  pages={1137 - 1149}
The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of "killer" proteins. On the other hand, data indicate that neurotrophic factors protect neurons in the same death paradigms by inducing expression of neuroprotective gene products. We now provide evidence that in embryonic rat hippocampal cell cultures, CHX protects neurons against oxidative insults… CONTINUE READING
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Amyloid b-peptide impairs glucose uptake in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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  • 1997
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