Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway

@article{Wang2007NeuroprotectionOS,
  title={Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway},
  author={Qing Wang and Quanguang Zhang and Dong-na Wu and Xiao-hui Yin and Guang-yi Zhang},
  journal={Acta Pharmacologica Sinica},
  year={2007},
  volume={28},
  pages={19-27}
}
AbstractAim:To investigate whether selenite, a known antioxidant, could decrease the activation of apoptosis signal regulating kinase 1/c-jun N-terminal kinase (ASK1/JNK) signaling cascade in cerebral ischemia/reperfusion (I/R) by activating the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in rat hippocampi, and the neuroprotective effect of selenite against ischemic injury after 15 min of transient brain ischemia.Methods:Transient global brain ischemia was induced by 4-vessel occlusion… CONTINUE READING
14 Citations
31 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…