Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+.

@article{Toulorge2011NeuroprotectionOM,
  title={Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+.},
  author={Damien Toulorge and Serge Guerreiro and Audrey Hild and Uwe Maskos and Etienne C. Hirsch and Patrick P Michel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 8},
  pages={2563-73}
}
Epidemiological and experimental evidence indicates that nicotine is protective for Parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this effect remains only partly characterized. To address this question, we established rat midbrain cultures maintained in experimental conditions that favor the selective and spontaneous loss of dopamine neurons. We report here that nicotine afforded neuroprotection to dopamine neurons (EC(50)=0.32 μM) but only in a situation where… CONTINUE READING