Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.

@article{Seo2009NeuroprotectionOE,
  title={Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.},
  author={Jeong Yeol Seo and Choong Hyun Lee and Jun Hwi Cho and Jung Hoon Choi and Ki-Yeon Yoo and Dae Won Kim and Ok kyu Park and Hua Li and Soo Young Choi and In Koo Hwang and Moo-ho Won},
  journal={Journal of the neurological sciences},
  year={2009},
  volume={285 1-2},
  pages={88-94}
}
Seleno-organic compound, ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), is a substrate with radical-scavenging activity. In this study, we observed the neuroprotective effects of ebselen against ischemic damage and on GABA shunt enzymes such as glutamic acid decarboxylase 67 (GAD67), GABA transaminse (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) in the hippocampal CA1 region after 5 min of transient forebrain ischemia in gerbils. For this, vehicle (physiological saline) or… CONTINUE READING