Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus.

@article{Yoo2006NeuroprotectionOA,
  title={Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus.},
  author={Young-Mi Yoo and C Lee and Uhn Lee and Yong-Jung Kim},
  journal={Experimental neurology},
  year={2006},
  volume={200 2},
  pages={407-17}
}
Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. In the present study, we examined the protective roles of adenoviral-vector-delivered GDNF (Ad-GDNF) in the hippocampus damaged by kainic-acid (KA)-induced excitotoxicity using GAD-67 immunoreactivity, immunoblot analysis, behavioral test, 5-bromo-2… CONTINUE READING