Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson’s disease

@article{Carriere2014NeuroprotectionBV,
  title={Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson’s disease},
  author={Candace H. Carriere and Na Hyea Kang and Lennard P Niles},
  journal={Neuroscience},
  year={2014},
  volume={267},
  pages={114-121}
}
Rotenone, which is used as a pesticide and insecticide, has been shown to cause systemic inhibition of mitochondrial complex I activity, with consequent degeneration of dopaminergic neurons within the substantia nigra and striatum, as observed in Parkinson's disease. A novel intrastriatal rotenone model of Parkinson's disease was used to examine the neuroprotective effects of valproic acid (VPA), which is known to upregulate neurotrophic factors and other protective proteins in the brain. Sham… CONTINUE READING

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Neuroprotection in a rotenone model of Parkinson's disease

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Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment.

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