Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia

@article{Gottlieb2006NeuroprotectionBT,
  title={Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia},
  author={Melvin B. Gottlieb and Roc{\'i}o Leal-Campanario and Mar{\'i}a del Rosario Campos-Esparza and M Victoria S{\'a}nchez-g{\'o}mez and Carlos F Matute},
  journal={Neurobiology of Disease},
  year={2006},
  volume={23},
  pages={374-386}
}
Brain ischemia induces neuronal loss which is caused in part by excitotoxicity and free radical formation. Here, we report that mangiferin and morin, two antioxidant polyphenols, are neuroprotective in both in vitro and in vivo models of ischemia. Cell death caused by glutamate in neuronal cultures was decreased in the presence of submicromolar concentrations of mangiferin or morin which in turn attenuated receptor-mediated calcium influx, oxidative stress as well as apoptosis. In addition… CONTINUE READING
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