Neuroprotection by the inhibition of apoptosis.

  title={Neuroprotection by the inhibition of apoptosis.},
  author={George R. Robertson and Stephen J Crocker and Donald W. Nicholson and J{\"o}rg Bernhard Schulz},
  journal={Brain pathology},
  volume={10 2},
Accumulating evidence strongly suggests that apoptosis contributes to neuronal cell death in a variety of neurodegenerative contexts. Activation of the cysteine protease caspase-3 appears to be a key event in the execution of apoptosis in the central nervous system (CNS). As a result, mice null for caspase-3 display considerable neuronal expansion usually resulting in death by the second week of life. At present, 14 caspase family members have been identified and subdivided into three subgroups… CONTINUE READING