Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1β generation

Abstract

The human immunodeficiency virus type-1 (HIV-1) coat protein, gp120, has been implicated in the progression of central nervous system (CNS) damage caused by HIV-1 infection (see Corasaniti et al.). Intracerebral (i.c.v.) injection of gp120 in adult rats causes neuropathological alterations, such as microglial cell activation, enhanced expression of the… (More)
DOI: 10.1038/sj.cdd.4401644

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