Neuroprotection by sildenafil: neuronal networks potentiation in acute experimental stroke.

Abstract

AIMS Sildenafil, a phosphodiesterase type 5 inhibitor, has been found to produce functional recovery in ischemic rats by increasing the cGMP level and triggering neurogenesis. The aim of this study was to investigate further sildenafil mechanisms. METHODS Male Sprague-Dawley rats underwent middle cerebral artery occlusion and reperfusion, followed by… (More)
DOI: 10.1111/cns.12162

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